Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study.

BackgroundDevelopment of an effective antiviral drug for Coronavirus Disease 2019 (COVID-19) is a global health priority.Although several candidate drugs have been identified through in vitro and in vivo models, consistent and compelling evidence from clinical studies is limited.The lack of evidence from clinical trials may stem in part from the im

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The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA

Abstract Enhanced expression of anti-apoptotic B-cell lymphoma 2 (BCL-2) protein is frequent in cancer.Targeting of BCL-2 with the specific inhibitor ABT-199 (Venetoclax) has significant clinical activity in malignant diseases such as chronic lymphocytic PHOTOSYNTHETIC PRODUCTIVITY OF LENTIL UNDER T HE ACTION OF BIOLOGICAL PREPARATIONS leukemia and

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An innovative system for uncoupled bending/torsion tests by tri-axis shaker: numerical simulations and experimental results

This work describes a new testing system for applying a coupled/uncoupled bendingtorsion loading in vibratory tests by a tri-axis shaker.The system is composed of a cylindrical specimen with eccentric tip masses, excited by horizontal and/or vertical base accelerations.The specimen tip is constrained by a lateral PHOTOSYNTHETIC PRODUCTIVITY OF LENT

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