BackgroundDevelopment of an effective antiviral drug for Coronavirus Disease 2019 (COVID-19) is a global health priority.Although several candidate drugs have been identified through in vitro and in vivo models, consistent and compelling evidence from clinical studies is limited.The lack of evidence from clinical trials may stem in part from the im
The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA
Abstract Enhanced expression of anti-apoptotic B-cell lymphoma 2 (BCL-2) protein is frequent in cancer.Targeting of BCL-2 with the specific inhibitor ABT-199 (Venetoclax) has significant clinical activity in malignant diseases such as chronic lymphocytic PHOTOSYNTHETIC PRODUCTIVITY OF LENTIL UNDER T HE ACTION OF BIOLOGICAL PREPARATIONS leukemia and
An innovative system for uncoupled bending/torsion tests by tri-axis shaker: numerical simulations and experimental results
This work describes a new testing system for applying a coupled/uncoupled bendingtorsion loading in vibratory tests by a tri-axis shaker.The system is composed of a cylindrical specimen with eccentric tip masses, excited by horizontal and/or vertical base accelerations.The specimen tip is constrained by a lateral PHOTOSYNTHETIC PRODUCTIVITY OF LENT
Self-Compassion in Relation to Self-Esteem, Self-Efficacy and Demographical Aspects
Abstract This study investigated relationships between self-compassion, self-efficacy, and self-esteem, as well as age and sex differences and other sociodemographic variables in relation to self-compassion.Four-hundred and thirty-two Brazilian adults (50% women) from Identification of confounders and estimating the causal effect of place of birth
Insights from chironomid oviposition is useful to visual pest control
Efficient visual pest control is still in its infant stages.Although being non-invasive, environmentally friendly and potentially cost effective, we still have not cracked the way to efficiently use it against epidemic vector-carrying and crop-infesting insects.Chironomid ovipostion can provide insights to key factors in ?????? ??????? ?a ???a?????